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Showing 1 to 12 of 283 entries
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Erratum to: Adherence and Persistence Across Antidepressant Therapeutic Classes: A Retrospective Claims Analysis Among Insured US Patients with Major Depressive Disorder (MDD).

CNS drugs

Keyloun KR, Hansen RN, Hepp Z, Gillard P, Thase ME, Devine EB.
PMID: 28451963
CNS Drugs. 2017 Jun;31(6):511. doi: 10.1007/s40263-017-0435-y.

No abstract available.

Erratum to: Pregnancy Outcomes Following In Utero Exposure to Lamotrigine: A Systematic Review and Meta-Analysis.

CNS drugs

Pariente G, Leibson T, Shulman T, Adams-Webber T, Barzilay E, Nulman I.
PMID: 28512694
CNS Drugs. 2017 Jun;31(6):451. doi: 10.1007/s40263-017-0439-7.

No abstract available.

Monomeric Octahedral Ruthenium(II) Complex Enabled meta-C-H Nitration of Arenes with Removable Auxiliaries.

Organic letters

Fan Z, Li J, Lu H, Wang DY, Wang C, Uchiyama M, Zhang A.
PMID: 28574271
Org Lett. 2017 Jun 16;19(12):3199-3202. doi: 10.1021/acs.orglett.7b01297. Epub 2017 Jun 02.

A removable oxime-assisted meta-C-H nitration of arenes is reported. Mechanistic investigations and DFT calculations reveal a new monomeric octahedral ruthenium(II) complex is responsible for the meta-selective nitration. Dioxygen as a cooxidant is crucial for achieving high conversion and good...

Histamine and Seizures : Implications for the Treatment of Epilepsy.

CNS drugs

Yokoyama H, Iinuma K.
PMID: 26071045
CNS Drugs. 1996 May;5(5):321-30. doi: 10.2165/00023210-199605050-00002.

Experimental studies have indicated that the central histaminergic neuron system plays an important role in the inhibition of seizures through stimulation of histamine H1 receptors, especially in the developmental period. This has therapeutic implications for currently available drugs that...

Erratum to: Oxycodone/Naloxone PR: A Review in Severe Refractory Restless Legs Syndrome.

CNS drugs

Frampton JE.
PMID: 26293746
CNS Drugs. 2015 Aug;29(8):713. doi: 10.1007/s40263-015-0274-7.

No abstract available.

Problems in the Assessment of Potential Antiepileptic Drugs.

CNS drugs

Eadie MJ.
PMID: 27520515
CNS Drugs. 1994 Mar;1(3):167-71. doi: 10.2165/00023210-199401030-00001.

Epilepsy is a serious and common neurological disorder for which effective and well tolerated new agents continue to be sought. While the assessment of potential antiepileptic agents in animals models of epilepsy poses few problems, such assessment in humans...

The Fluoxetine and Suicide Controversy : A Review of the Evidence.

CNS drugs

Healy D.
PMID: 27520521
CNS Drugs. 1994 Mar;1(3):223-31. doi: 10.2165/00023210-199401030-00007.

Evidence is emerging that a range of psychotropic drugs may precipitate akathisia and/or panic reactions in predisposed patients. The use of fluoxetine has hitherto been the most notable example of this occurrence. These reactions may foster the genesis of...

Relapse Prevention in Alcoholism : Recent Advances and Future Possibilities.

CNS drugs

Soyka M.
PMID: 27520754
CNS Drugs. 1997 Apr;7(4):313-27. doi: 10.2165/00023210-199707040-00004.

Most psychotropic drugs, such as antipsychotics, lithium and tricyclic antidepressants, do not improve alcohol (ethanol) abstinence rates, at least in alcohol-dependent patients who do not have a comorbid psychiatric disorder. In recent years, numerous studies have been published that...

Mixed Anxiety and Depression : Diagnosis and Treatment Options.

CNS drugs

Bakish D, Habib R, Hooper CL.
PMID: 27521010
CNS Drugs. 1998 Apr;9(4):271-80. doi: 10.2165/00023210-199809040-00003.

Symptoms of anxiety and depression often appear together in patients, either as 2 discrete disorders, such as major depressive disorder and panic disorder, or as a combination of symptoms not meeting criteria for specific disorders. The social, economic, occupational...

CNS Adverse Effects of Nonsteroidal Anti-Inflammatory Drugs : Therapeutic Implications.

CNS drugs

Morgan A, Clark D.
PMID: 27521013
CNS Drugs. 1998 Apr;9(4):281-90. doi: 10.2165/00023210-199809040-00004.

It is difficult to obtain valid estimations of the true incidence of CNS effects associated with nonsteroidal anti-inflammatory drugs (NSAIDs) from spontaneously reported adverse reactions. This is because the reporting rates of adverse reactions are low and the total...

Probabilistic Approach to Generating MPOs and Its Application as a Scoring Function for CNS Drugs.

ACS medicinal chemistry letters

Gunaydin H.
PMID: 26819672
ACS Med Chem Lett. 2015 Dec 02;7(1):89-93. doi: 10.1021/acsmedchemlett.5b00390. eCollection 2016 Jan 14.

Multiparameter optimization (MPO) scoring functions are popular tools for providing guidance on how to design desired molecules in medicinal chemistry. The utility of a new probabilistic MPO (pMPO) scoring function method and its application as a scoring function for...

Prevention of schizophrenia: can it be achieved?.

CNS drugs

Lee C, McGlashan TH, Woods SW.
PMID: 15740175
CNS Drugs. 2005;19(3):193-206. doi: 10.2165/00023210-200519030-00002.

Schizophrenia is a serious mental disorder with a profound impact on patients, their caregivers and society. It is also an expensive disorder to treat, despite being relatively rare. In this paper, prevention of schizophrenia is described in terms of...

Showing 1 to 12 of 283 entries